Hesperetin-5,7,3’-O-triacetate suppresses airway hyperresponsiveness in ovalbumin-sensitized and challenged mice without reversing xylazine/ketamine-induced anesthesia in normal mice

BACKGROUND: We recently reported that hesperetin-5,7,3’-O-triacetate (HTA) dually inhibited phosphodiesterase (PDE)3/4 with a therapeutic ratio of 20.8. The application and development of PDE4 inhibitors for treating asthma or COPD are limited by their side effects, such as nausea, vomiting and gast...

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Detalles Bibliográficos
Autores principales: Yang, You-Lan, Chen, Chi-Li, Chen, Chi-Ming, Ko, Wun-Chang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5450382/
https://www.ncbi.nlm.nih.gov/pubmed/28558784
http://dx.doi.org/10.1186/s40360-017-0146-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5450382/
https://www.ncbi.nlm.nih.gov/pubmed/28558784
http://dx.doi.org/10.1186/s40360-017-0146-5

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