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Hesperetin-5,7,3’-O-triacetate suppresses airway hyperresponsiveness in ovalbumin-sensitized and challenged mice without reversing xylazine/ketamine-induced anesthesia in normal mice

BACKGROUND: We recently reported that hesperetin-5,7,3’-O-triacetate (HTA) dually inhibited phosphodiesterase (PDE)3/4 with a therapeutic ratio of 20.8. The application and development of PDE4 inhibitors for treating asthma or COPD are limited by their side effects, such as nausea, vomiting and gast...

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Detalles Bibliográficos
Autores principales:	Yang, You-Lan, Chen, Chi-Li, Chen, Chi-Ming, Ko, Wun-Chang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5450382/ https://www.ncbi.nlm.nih.gov/pubmed/28558784 http://dx.doi.org/10.1186/s40360-017-0146-5

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