Belatacept Does Not Inhibit Follicular T Cell-Dependent B-Cell Differentiation in Kidney Transplantation

Humoral alloreactivity has been recognized as a common cause of kidney transplant dysfunction. B-cell activation, differentiation, and antibody production are dependent on IL-21(+)CXCR5(+)follicular T-helper (Tfh) cells. Here, we studied whether belatacept, an inhibitor of the costimulatory CD28-CD8...

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Detalles Bibliográficos
Autores principales: de Graav, Gretchen N., Hesselink, Dennis A., Dieterich, Marjolein, Kraaijeveld, Rens, Verschoor, Wenda, Roelen, Dave L., Litjens, Nicolle H. R., Chong, Anita S., Weimar, Willem, Baan, Carla C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5450507/
https://www.ncbi.nlm.nih.gov/pubmed/28620390
http://dx.doi.org/10.3389/fimmu.2017.00641

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5450507/
https://www.ncbi.nlm.nih.gov/pubmed/28620390
http://dx.doi.org/10.3389/fimmu.2017.00641

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