Assessment of Heparanase-Mediated Angiogenesis Using Microvascular Endothelial Cells: Identification of λ-Carrageenan Derivative as a Potent Anti Angiogenic Agent

Heparanase is overexpressed by tumor cells and degrades the extracellular matrix proteoglycans through cleavage of heparan sulfates (HS), allowing pro-angiogenic factor release and thus playing a key role in tumor angiogenesis and metastasis. Here we propose new HS analogs as potent heparanase inhib...

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Detalles Bibliográficos
Autores principales: Poupard, Nicolas, Badarou, Pamela, Fasani, Fabienne, Groult, Hugo, Bridiau, Nicolas, Sannier, Frédéric, Bordenave-Juchereau, Stéphanie, Kieda, Claudine, Piot, Jean-Marie, Grillon, Catherine, Fruitier-Arnaudin, Ingrid, Maugard, Thierry
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5450540/
https://www.ncbi.nlm.nih.gov/pubmed/28486399
http://dx.doi.org/10.3390/md15050134

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5450540/
https://www.ncbi.nlm.nih.gov/pubmed/28486399
http://dx.doi.org/10.3390/md15050134

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