Therapeutic silence of pleiotrophin by targeted delivery of siRNA and its effect on the inhibition of tumor growth and metastasis

Pleiotrophin (PTN) is a secreted cytokine that is expressed in various cancer cell lines and human tumor such as colon cancer, lung cancer, gastric cancer and melanoma. It plays significant roles in angiogenesis, metastasis, differentiation and cell growth. The expression of PTN in the adult is limi...

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Detalles Bibliográficos
Autores principales: Zha, Lisha, He, Lichun, Xie, Weidong, Cheng, Jin, Li, Tong, Mohsen, Mona O., Lei, Fan, Storni, Federico, Bachmann, Martin, Chen, Hongquan, Zhang, Yaou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5451024/
https://www.ncbi.nlm.nih.gov/pubmed/28562667
http://dx.doi.org/10.1371/journal.pone.0177964

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5451024/
https://www.ncbi.nlm.nih.gov/pubmed/28562667
http://dx.doi.org/10.1371/journal.pone.0177964

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