Quantitative analysis of the CD4(+) T cell response to therapeutic antibodies in healthy donors using a novel T cell:PBMC assay

Many biopharmaceuticals (BPs) are known to be immunogenic in the clinic, which can result in modified pharmacokinetics, reduced efficacy, allergic reactions and anaphylaxis. During recent years, several technologies to predict immunogenicity have been introduced, but the predictive value is still co...

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Detalles Bibliográficos
Autores principales: Schultz, Heidi S., Reedtz-Runge, Stine Louise, Bäckström, B. Thomas, Lamberth, Kasper, Pedersen, Christian R., Kvarnhammar, Anne M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5451071/
https://www.ncbi.nlm.nih.gov/pubmed/28562666
http://dx.doi.org/10.1371/journal.pone.0178544

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5451071/
https://www.ncbi.nlm.nih.gov/pubmed/28562666
http://dx.doi.org/10.1371/journal.pone.0178544

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