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Quantitative analysis of the CD4(+) T cell response to therapeutic antibodies in healthy donors using a novel T cell:PBMC assay
Many biopharmaceuticals (BPs) are known to be immunogenic in the clinic, which can result in modified pharmacokinetics, reduced efficacy, allergic reactions and anaphylaxis. During recent years, several technologies to predict immunogenicity have been introduced, but the predictive value is still co...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5451071/ https://www.ncbi.nlm.nih.gov/pubmed/28562666 http://dx.doi.org/10.1371/journal.pone.0178544 |