Loss of Ranbp2 in motoneurons causes disruption of nucleocytoplasmic and chemokine signaling, proteostasis of hnRNPH3 and Mmp28, and development of amyotrophic lateral sclerosis-like syndromes

The pathogenic drivers of sporadic and familial motor neuron disease (MND), such amyotrophic lateral sclerosis (ALS), are unknown. MND impairs the Ran GTPase cycle, which controls nucleocytoplasmic transport, ribostasis and proteostasis; however, cause-effect mechanisms of Ran GTPase modulators in m...

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Detalles Bibliográficos
Autores principales: Cho, Kyoung-in, Yoon, Dosuk, Qiu, Sunny, Danziger, Zachary, Grill, Warren M., Wetsel, William C., Ferreira, Paulo A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2017
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5451164/
https://www.ncbi.nlm.nih.gov/pubmed/28100513
http://dx.doi.org/10.1242/dmm.027730

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5451164/
https://www.ncbi.nlm.nih.gov/pubmed/28100513
http://dx.doi.org/10.1242/dmm.027730

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