Blood RNA biomarkers in prodromal PARK4 and rapid eye movement sleep behavior disorder show role of complexin 1 loss for risk of Parkinson's disease

Parkinson's disease (PD) is a frequent neurodegenerative process in old age. Accumulation and aggregation of the lipid-binding SNARE complex component α-synuclein (SNCA) underlies this vulnerability and defines stages of disease progression. Determinants of SNCA levels and mechanisms of SNCA ne...

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Detalles Bibliográficos
Autores principales: Lahut, Suna, Gispert, Suzana, Ömür, Özgür, Depboylu, Candan, Seidel, Kay, Domínguez-Bautista, Jorge Antolio, Brehm, Nadine, Tireli, Hülya, Hackmann, Karl, Pirkevi, Caroline, Leube, Barbara, Ries, Vincent, Reim, Kerstin, Brose, Nils, den Dunnen, Wilfred F., Johnson, Madrid, Wolf, Zsuzsanna, Schindewolf, Marc, Schrempf, Wiebke, Reetz, Kathrin, Young, Peter, Vadasz, David, Frangakis, Achilleas S., Schröck, Evelin, Steinmetz, Helmuth, Jendrach, Marina, Rüb, Udo, Başak, Ayşe Nazlı, Oertel, Wolfgang, Auburger, Georg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2017
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5451169/
https://www.ncbi.nlm.nih.gov/pubmed/28108469
http://dx.doi.org/10.1242/dmm.028035

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5451169/
https://www.ncbi.nlm.nih.gov/pubmed/28108469
http://dx.doi.org/10.1242/dmm.028035

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