Genetic mutations linked to Parkinson's disease differentially control nucleolar activity in pre-symptomatic mouse models

Genetic mutations underlying neurodegenerative disorders impair ribosomal DNA (rDNA) transcription suggesting that nucleolar dysfunction could be a novel pathomechanism in polyglutamine diseases and in certain forms of amyotrophic lateral sclerosis/frontotemporal dementia. Here, we investigated nucl...

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Detalles Bibliográficos
Autores principales: Evsyukov, Valentin, Domanskyi, Andrii, Bierhoff, Holger, Gispert, Suzana, Mustafa, Rasem, Schlaudraff, Falk, Liss, Birgit, Parlato, Rosanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2017
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5451170/
https://www.ncbi.nlm.nih.gov/pubmed/28360124
http://dx.doi.org/10.1242/dmm.028092

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5451170/
https://www.ncbi.nlm.nih.gov/pubmed/28360124
http://dx.doi.org/10.1242/dmm.028092

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