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Compliant substratum guides endothelial commitment from human pluripotent stem cells

The role of mechanical regulation in driving human induced pluripotent stem cell (hiPSC) differentiation has been minimally explored. Although endothelial cell (EC) fate from hiPSCs has been demonstrated using small molecules to drive mesoderm induction, the effects of substrate stiffness with regar...

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Detalles Bibliográficos
Autores principales: Smith, Quinton, Chan, Xin Yi, Carmo, Ana Maria, Trempel, Michelle, Saunders, Michael, Gerecht, Sharon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5451190/
https://www.ncbi.nlm.nih.gov/pubmed/28580421
http://dx.doi.org/10.1126/sciadv.1602883