Molecular isoforms of high-mobility group box 1 are mechanistic biomarkers for epilepsy

Approximately 30% of epilepsy patients do not respond to antiepileptic drugs, representing an unmet medical need. There is evidence that neuroinflammation plays a pathogenic role in drug-resistant epilepsy. The high-mobility group box 1 (HMGB1)/TLR4 axis is a key initiator of neuroinflammation follo...

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Detalles Bibliográficos
Autores principales: Walker, Lauren Elizabeth, Frigerio, Federica, Ravizza, Teresa, Ricci, Emanuele, Tse, Karen, Jenkins, Rosalind E., Sills, Graeme John, Jorgensen, Andrea, Porcu, Luca, Thippeswamy, Thimmasettappa, Alapirtti, Tiina, Peltola, Jukka, Brodie, Martin J., Park, Brian Kevin, Marson, Anthony Guy, Antoine, Daniel James, Vezzani, Annamaria, Pirmohamed, Munir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5451237/
https://www.ncbi.nlm.nih.gov/pubmed/28504645
http://dx.doi.org/10.1172/JCI92001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5451237/
https://www.ncbi.nlm.nih.gov/pubmed/28504645
http://dx.doi.org/10.1172/JCI92001

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