Proof-of-Concept Gene Editing for the Murine Model of Inducible Arginase-1 Deficiency

Arginase-1 deficiency in humans is a rare genetic disorder of metabolism resulting from a loss of arginase-1, leading to impaired ureagenesis, hyperargininemia and neurological deficits. Previously, we generated a tamoxifen-inducible arginase-1 deficient mouse model harboring a deletion of Arg1 exon...

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Detalles Bibliográficos
Autores principales: Sin, Yuan Yan, Price, Phillipe R., Ballantyne, Laurel L., Funk, Colin D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5451454/
https://www.ncbi.nlm.nih.gov/pubmed/28566761
http://dx.doi.org/10.1038/s41598-017-02927-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5451454/
https://www.ncbi.nlm.nih.gov/pubmed/28566761
http://dx.doi.org/10.1038/s41598-017-02927-2

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