Identification of a small molecule that primes the type I interferon response to cytosolic DNA

The type I interferon response plays a pivotal role in host defense against infectious agents and tumors, and promising therapeutic approaches rely on small molecules designed to boost this system. To identify such compounds, we developed a high-throughput screening assay based on HEK-293 cells expr...

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Detalles Bibliográficos
Autores principales: Khiar, Samira, Lucas-Hourani, Marianne, Nisole, Sébastien, Smith, Nikaïa, Helynck, Olivier, Bourgine, Maryline, Ruffié, Claude, Herbeuval, Jean-Philippe, Munier-Lehmann, Hélène, Tangy, Frédéric, Vidalain, Pierre-Olivier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5451460/
https://www.ncbi.nlm.nih.gov/pubmed/28566766
http://dx.doi.org/10.1038/s41598-017-02776-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5451460/
https://www.ncbi.nlm.nih.gov/pubmed/28566766
http://dx.doi.org/10.1038/s41598-017-02776-z

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