Discovery of a Diaminopyrimidine FLT3 Inhibitor Active against Acute Myeloid Leukemia

[Image: see text] Profiling of the kinase-binding capabilities of an aminopyrimidine analogue detected in a cellular screen of the St. Jude small-molecule collection led to the identification of a novel series of FMS-like tyrosine kinase 3 (FLT3) inhibitors. Structure–activity relationship studies l...

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Detalles Bibliográficos
Autores principales: Jarusiewicz, Jamie A., Jeon, Jae Yoon, Connelly, Michele C., Chen, Yizhe, Yang, Lei, Baker, Sharyn D., Guy, R. Kiplin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2017
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5452050/
https://www.ncbi.nlm.nih.gov/pubmed/28580438
http://dx.doi.org/10.1021/acsomega.7b00144