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Discovery of a Diaminopyrimidine FLT3 Inhibitor Active against Acute Myeloid Leukemia
[Image: see text] Profiling of the kinase-binding capabilities of an aminopyrimidine analogue detected in a cellular screen of the St. Jude small-molecule collection led to the identification of a novel series of FMS-like tyrosine kinase 3 (FLT3) inhibitors. Structure–activity relationship studies l...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5452050/ https://www.ncbi.nlm.nih.gov/pubmed/28580438 http://dx.doi.org/10.1021/acsomega.7b00144 |