Allosteric DNA nanoswitches for controlled release of a molecular cargo triggered by biological inputs

Here we demonstrate the rational design of a new class of DNA-based nanoswitches which are allosterically regulated by specific biological targets, antibodies and transcription factors, and are able to load and release a molecular cargo (i.e. doxorubicin) in a controlled fashion. In our first model...

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Detalles Bibliográficos
Autores principales: Rossetti, Marianna, Ranallo, Simona, Idili, Andrea, Palleschi, Giuseppe, Porchetta, Alessandro, Ricci, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2017
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5452262/
https://www.ncbi.nlm.nih.gov/pubmed/28572901
http://dx.doi.org/10.1039/c6sc03404g

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5452262/
https://www.ncbi.nlm.nih.gov/pubmed/28572901
http://dx.doi.org/10.1039/c6sc03404g

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