ApoE isoforms differentially regulates cleavage and secretion of BDNF

Apolipoprotein E4 (ApoE4) is a major genetic risk factor for sporadic or late onset Alzheimer’s disease (AD). Brain-derived neurotrophic factor (BDNF) is decreased by 3 to 4-fold in the brains of AD patients at autopsy. ApoE4 mice also have reduced BDNF levels. However, there have been no reports re...

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Detalles Bibliográficos
Autores principales: Sen, Abhik, Nelson, Thomas J., Alkon, Daniel L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5452344/
https://www.ncbi.nlm.nih.gov/pubmed/28569173
http://dx.doi.org/10.1186/s13041-017-0301-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5452344/
https://www.ncbi.nlm.nih.gov/pubmed/28569173
http://dx.doi.org/10.1186/s13041-017-0301-3

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