Seed-effect modeling improves the consistency of genome-wide loss-of-function screens and identifies synthetic lethal vulnerabilities in cancer cells

BACKGROUND: Genome-wide loss-of-function profiling is widely used for systematic identification of genetic dependencies in cancer cells; however, the poor reproducibility of RNA interference (RNAi) screens has been a major concern due to frequent off-target effects. Currently, a detailed understandi...

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Detalles Bibliográficos
Autores principales: Jaiswal, Alok, Peddinti, Gopal, Akimov, Yevhen, Wennerberg, Krister, Kuznetsov, Sergey, Tang, Jing, Aittokallio, Tero
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5452371/
https://www.ncbi.nlm.nih.gov/pubmed/28569207
http://dx.doi.org/10.1186/s13073-017-0440-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5452371/
https://www.ncbi.nlm.nih.gov/pubmed/28569207
http://dx.doi.org/10.1186/s13073-017-0440-2

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