Cargando…

A knowledge-based framework for the discovery of cancer-predisposing variants using large-scale sequencing breast cancer data

BACKGROUND: The landscape of cancer-predisposing genes has been extensively investigated in the last 30 years with various methodologies ranging from candidate gene to genome-wide association studies. However, sequencing data are still poorly exploited in cancer predisposition studies due to the lac...

Descripción completa

Detalles Bibliográficos
Autores principales:	Melloni, Giorgio E. M., Mazzarella, Luca, Bernard, Loris, Bodini, Margherita, Russo, Anna, Luzi, Lucilla, Pelicci, Pier Giuseppe, Riva, Laura
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5452392/ https://www.ncbi.nlm.nih.gov/pubmed/28569218 http://dx.doi.org/10.1186/s13058-017-0854-1

Ejemplares similares

DOTS-Finder: a comprehensive tool for assessing driver genes in cancer genomes
por: Melloni, Giorgio EM, et al.
Publicado: (2014)

Genomics of Acute Myeloid Leukemia: The Next Generation
por: Riva, Laura, et al.
Publicado: (2012)

Cerebro: interactive visualization of scRNA-seq data
por: Hillje, Roman, et al.
Publicado: (2020)

p53 Loss in Breast Cancer Leads to Myc Activation, Increased Cell Plasticity, and Expression of a Mitotic Signature with Prognostic Value
por: Santoro, Angela, et al.
Publicado: (2019)

XenoCell: classification of cellular barcodes in single cell experiments from xenograft samples
por: Cheloni, Stefano, et al.
Publicado: (2021)

Tumor mutational burden quantification from targeted gene panels: major advancements and challenges
por: Fancello, Laura, et al.
Publicado: (2019)

Acute promyelocytic leukemias share cooperative mutations with other myeloid-leukemia subgroups
por: Riva, L, et al.
Publicado: (2014)

Acute promyelocytic leukemias share cooperative mutations with other myeloid-leukemia subgroups
por: Riva, L, et al.
Publicado: (2013)

Development of Personalized Therapeutic Strategies by Targeting Actionable Vulnerabilities in Metastatic and Chemotherapy-Resistant Breast Cancer PDXs
por: Punzi, Simona, et al.
Publicado: (2019)

Oxidative stress activates a specific p53 transcriptional response that regulates cellular senescence and aging
por: Gambino, Valentina, et al.
Publicado: (2013)

Ancestry-specific predisposing germline variants in cancer
por: Oak, Ninad, et al.
Publicado: (2020)

Time makes histone H3 modifications drift in mouse liver
por: Hillje, Roman, et al.
Publicado: (2022)

Epigenomic profiling of archived FFPE tissues by enhanced PAT-ChIP (EPAT-ChIP) technology
por: Amatori, Stefano, et al.
Publicado: (2018)

PNPLA3 overexpression results in reduction of proteins predisposing to fibrosis
por: Pingitore, Piero, et al.
Publicado: (2016)

Semantic and Geographical Analysis of COVID-19 Trials Reveals a Fragmented Clinical Research Landscape Likely to Impair Informativeness
por: Tini, Giulia, et al.
Publicado: (2020)

GASOLINE: detecting germline and somatic structural variants from long-reads data
por: Magi, Alberto, et al.
Publicado: (2023)

Genome-wide mapping of human DNA-replication origins: Levels of transcription at ORC1 sites regulate origin selection and replication timing
por: Dellino, Gaetano Ivan, et al.
Publicado: (2013)

Practice pointer: care of men with cancer-predisposing BRCA variants
por: Horton, Rachel, et al.
Publicado: (2021)

Quantifying geographical accessibility to cancer clinical trials in different income landscapes
por: Tini, G., et al.
Publicado: (2022)

Awaking stem cells from dormancy: growing old and fighting cancer
por: Viale, Andrea, et al.
Publicado: (2009)

Mutations targeting the coagulation pathway are enriched in brain metastases
por: Richichi, Cristina, et al.
Publicado: (2017)

LowMACA: exploiting protein family analysis for the identification of rare driver mutations in cancer
por: Melloni, Giorgio E. M., et al.
Publicado: (2016)

AML1/ETO Oncoprotein Is Directed to AML1 Binding Regions and Co-Localizes with AML1 and HEB on Its Targets
por: Gardini, Alessandro, et al.
Publicado: (2008)

Maintenance of leukemic cell identity by the activity of the Polycomb complex PRC1 in mice
por: Rossi, Alessandra, et al.
Publicado: (2016)

Germline Variants of CYBA and TRPM4 Predispose to Familial Colorectal Cancer
por: Zhu, Lizhen, et al.
Publicado: (2022)

Prevalence of pathogenic variants in cancer‐predisposing genes in second cancer after childhood solid cancers
por: Yoshida, Masanori, et al.
Publicado: (2023)

Master protocols in immuno-oncology: do novel drugs deserve novel designs?
por: Mazzarella, Luca, et al.
Publicado: (2020)

Heating cancer stem cells to reduce tumor relapse
por: Pelicci, Pier Giuseppe, et al.
Publicado: (2011)

Why does obesity promote cancer? Epidemiology, biology, and open questions
por: Mazzarella, Luca
Publicado: (2015)

Introducing Infectious Agents and Cancer
por: Buonaguro, Franco M, et al.
Publicado: (2006)

Does Sphincteroplasty Predispose to Bile Duct Cancer?
por: Strong, Russell W.
Publicado: (1999)

Clinical Significance of Germline Cancer Predisposing Variants in Unselected Patients with Pancreatic Adenocarcinoma
por: Fountzilas, Elena, et al.
Publicado: (2021)

Combinations of Low-Frequency Genetic Variants Might Predispose to Familial Pancreatic Cancer
por: Slater, Emily P., et al.
Publicado: (2021)

Common variants in breast cancer risk loci predispose to distinct tumor subtypes
por: Ahearn, Thomas U., et al.
Publicado: (2022)

Association between germline pathogenic variants in cancer‐predisposing genes and lymphoma risk
por: Usui, Yoshiaki, et al.
Publicado: (2022)

Prevalence of Germline Pathogenic Variants in Cancer Predisposing Genes in Czech and Belgian Pancreatic Cancer Patients
por: Wieme, Greet, et al.
Publicado: (2021)

Blood Vessels and Peripheral Nerves as Key Players in Cancer Progression and Therapy Resistance
por: Roda, Niccolò, et al.
Publicado: (2021)

Insights into the beneficial effect of caloric/ dietary restriction for a healthy and prolonged life
por: Pallavi, Rani, et al.
Publicado: (2012)

p53 and aging: role of p66Shc
por: Migliaccio, Enrica, et al.
Publicado: (2013)

The P66Shc/Mitochondrial Permeability Transition Pore Pathway Determines Neurodegeneration
por: Savino, Costanza, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_v7u5ghj7v89jbg0vipoap2rvdv