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Identification of a type I nitroreductase gene in non-virulent Trypanosoma rangeli

Trypanosomatid type I nitroreductases (NTRs), i.e., mitochondrial enzymes that metabolise nitroaromatic pro-drugs, are essential for parasite growth, infection, and survival. Here, a type I NTR of non-virulent protozoan Trypanosoma rangeli is described and compared to those of other trypanosomatids....

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Detalles Bibliográficos
Autores principales: Montenegro, Marjorie, Cuervo, Claudia, Cardenas, Constanza, Duarte, Silvia, Díaz, Jenny R, Thomas, M Carmen, Lopez, Manuel C, Puerta, Concepcion J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Instituto Oswaldo Cruz, Ministério da Saúde 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5452488/
https://www.ncbi.nlm.nih.gov/pubmed/28591312
http://dx.doi.org/10.1590/0074-02760160532