Compound 48/80, a mast cell degranulator, causes oxidative damage by enhancing vitamin C synthesis via reduced glutathione depletion and lipid peroxidation through neutrophil infiltration in rat livers

In this study, we examined whether compound 48/80 (C48/80), a mast cell degranulator, causes hepatic oxidative damage in rats. Serum and liver biochemical parameters were determined 0.5, 3 or 6 h after a single treatment with C48/80 (0.75 mg/kg). Serum histamine and serotonin levels increased 0.5 h...

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Detalles Bibliográficos
Autores principales: Ohta, Yosihiji, Yashiro, Koji, Ohashi, Koji, Horikoshi, Yosuke, Kusumoto, Chiaki, Matsura, Tatsuya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: the Society for Free Radical Research Japan 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5453024/
https://www.ncbi.nlm.nih.gov/pubmed/28584400
http://dx.doi.org/10.3164/jcbn.16-89

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5453024/
https://www.ncbi.nlm.nih.gov/pubmed/28584400
http://dx.doi.org/10.3164/jcbn.16-89

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