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Microfluidic Mobility Shift Assay for Real-Time Analysis of Peptide N-Palmitoylation
The Hedgehog pathway is a key developmental signaling pathway but is also implicated in many types of cancer. The extracellular signaling protein Sonic hedgehog (Shh) requires dual lipidation for functional signaling, whereby N-terminal palmitoylation is performed by the enzyme Hedgehog acyltransfer...
Autores principales: | Lanyon-Hogg, Thomas, Patel, Neki V., Ritzefeld, Markus, Boxall, Katherine J., Burke, Rosemary, Blagg, Julian, Magee, Anthony I., Tate, Edward W. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5453399/ https://www.ncbi.nlm.nih.gov/pubmed/28296537 http://dx.doi.org/10.1177/2472555216689529 |
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