Statin and rottlerin small-molecule inhibitors restrict colon cancer progression and metastasis via MACC1

MACC1 (Metastasis Associated in Colon Cancer 1) is a key driver and prognostic biomarker for cancer progression and metastasis in a large variety of solid tumor types, particularly colorectal cancer (CRC). However, no MACC1 inhibitors have been identified yet. Therefore, we aimed to target MACC1 exp...

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Detalles Bibliográficos
Autores principales: Juneja, Manisha, Kobelt, Dennis, Walther, Wolfgang, Voss, Cynthia, Smith, Janice, Specker, Edgar, Neuenschwander, Martin, Gohlke, Björn-Oliver, Dahlmann, Mathias, Radetzki, Silke, Preissner, Robert, von Kries, Jens Peter, Schlag, Peter Michael, Stein, Ulrike
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5453412/
https://www.ncbi.nlm.nih.gov/pubmed/28570591
http://dx.doi.org/10.1371/journal.pbio.2000784

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5453412/
https://www.ncbi.nlm.nih.gov/pubmed/28570591
http://dx.doi.org/10.1371/journal.pbio.2000784

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