Targeting YAP/TAZ-TEAD protein-protein interactions using fragment-based and computational modeling approaches

The Hippo signaling pathway, which is implicated in the regulation of organ size, has emerged as a potential target for the development of cancer therapeutics. YAP, TAZ (transcription co-activators) and TEAD (transcription factor) are the downstream transcriptional machinery and effectors of the pat...

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Detalles Bibliográficos
Autores principales: Kaan, Hung Yi Kristal, Sim, Adelene Y. L., Tan, Siew Kim Joyce, Verma, Chandra, Song, Haiwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5453487/
https://www.ncbi.nlm.nih.gov/pubmed/28570566
http://dx.doi.org/10.1371/journal.pone.0178381

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5453487/
https://www.ncbi.nlm.nih.gov/pubmed/28570566
http://dx.doi.org/10.1371/journal.pone.0178381

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