IGF1 and IGF2 specificities to the two insulin receptor isoforms are determined by insulin receptor amino acid 718

METHODS: Alanine scan of insulin receptor (IR)-B exon 11 and site-directed mutagenesis of amino acid 718 in human IR-A and IR-B were performed. Ligand affinities to wild type and mutated receptors were studied by displacement of radioactive insulin in binding assay on secreted soluble midi receptors...

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Detalles Bibliográficos
Autores principales: Andersen, Mie, Nørgaard-Pedersen, Dorte, Brandt, Jakob, Pettersson, Ingrid, Slaaby, Rita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5453582/
https://www.ncbi.nlm.nih.gov/pubmed/28570711
http://dx.doi.org/10.1371/journal.pone.0178885

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5453582/
https://www.ncbi.nlm.nih.gov/pubmed/28570711
http://dx.doi.org/10.1371/journal.pone.0178885

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