Preclinical Evaluation of a Lentiviral Vector for Huntingtin Silencing

Huntington’s disease (HD) is an autosomal dominant neurodegenerative disorder resulting from a polyglutamine expansion in the huntingtin (HTT) protein. There is currently no cure for this disease, but recent studies suggest that RNAi to downregulate the expression of both normal and mutant HTT is a...

Descripción completa

Detalles Bibliográficos
Autores principales: Cambon, Karine, Zimmer, Virginie, Martineau, Sylvain, Gaillard, Marie-Claude, Jarrige, Margot, Bugi, Aurore, Miniarikova, Jana, Rey, Maria, Hassig, Raymonde, Dufour, Noelle, Auregan, Gwenaelle, Hantraye, Philippe, Perrier, Anselme L., Déglon, Nicole
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5453866/
https://www.ncbi.nlm.nih.gov/pubmed/28603746
http://dx.doi.org/10.1016/j.omtm.2017.05.001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5453866/
https://www.ncbi.nlm.nih.gov/pubmed/28603746
http://dx.doi.org/10.1016/j.omtm.2017.05.001

Ejemplares similares