Mitochondrial targeting by dichloroacetate improves outcome following hemorrhagic shock

Hemorrhagic shock is a leading cause of death in people under the age of 45 and accounts for almost half of trauma-related deaths. In order to develop a treatment strategy based on potentiating mitochondrial function, we investigated the effect of the orphan drug dichloroacetate (DCA) on survival in...

Descripción completa

Detalles Bibliográficos
Autores principales: Subramani, Kumar, Lu, Sumin, Warren, Marie, Chu, Xiaogang, Toque, Haroldo A., Caldwell, R. William, Diamond, Michael P., Raju, Raghavan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5453974/
https://www.ncbi.nlm.nih.gov/pubmed/28572638
http://dx.doi.org/10.1038/s41598-017-02495-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5453974/
https://www.ncbi.nlm.nih.gov/pubmed/28572638
http://dx.doi.org/10.1038/s41598-017-02495-5

Ejemplares similares