A nucleotide-controlled conformational switch modulates the activity of eukaryotic IMP dehydrogenases

Inosine-5′-monophosphate dehydrogenase (IMPDH) is an essential enzyme for nucleotide metabolism and cell proliferation. Despite IMPDH is the target of drugs with antiviral, immunosuppressive and antitumor activities, its physiological mechanisms of regulation remain largely unknown. Using the enzyme...

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Detalles Bibliográficos
Autores principales: Buey, Rubén M., Fernández-Justel, David, Marcos-Alcalde, Íñigo, Winter, Graeme, Gómez-Puertas, Paulino, de Pereda, José María, Luis Revuelta, José
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5454003/
https://www.ncbi.nlm.nih.gov/pubmed/28572600
http://dx.doi.org/10.1038/s41598-017-02805-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5454003/
https://www.ncbi.nlm.nih.gov/pubmed/28572600
http://dx.doi.org/10.1038/s41598-017-02805-x

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