GLP-1 receptor signalling promotes β-cell glucose metabolism via mTOR-dependent HIF-1α activation

Glucagon-like peptide-1 (GLP-1) promotes insulin secretion from pancreatic β-cells in a glucose dependent manner. Several pathways mediate this action by rapid, kinase phosphorylation-dependent, but gene expression-independent mechanisms. Since GLP-1-induced insulin secretion requires glucose metabo...

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Detalles Bibliográficos
Autores principales: Carlessi, Rodrigo, Chen, Younan, Rowlands, Jordan, Cruzat, Vinicius F., Keane, Kevin N., Egan, Lauren, Mamotte, Cyril, Stokes, Rebecca, Gunton, Jenny E., Bittencourt, Paulo Ivo Homem de, Newsholme, Philip
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5454020/
https://www.ncbi.nlm.nih.gov/pubmed/28572610
http://dx.doi.org/10.1038/s41598-017-02838-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5454020/
https://www.ncbi.nlm.nih.gov/pubmed/28572610
http://dx.doi.org/10.1038/s41598-017-02838-2

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