Increasing N-acetylaspartate in the Brain during Postnatal Myelination Does Not Cause the CNS Pathologies of Canavan Disease

Canavan disease is caused by mutations in the gene encoding aspartoacylase (ASPA), a deacetylase that catabolizes N-acetylaspartate (NAA). The precise involvement of elevated NAA in the pathogenesis of Canavan disease is an ongoing debate. In the present study, we tested the effects of elevated NAA...

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Detalles Bibliográficos
Autores principales: Appu, Abhilash P., Moffett, John R., Arun, Peethambaran, Moran, Sean, Nambiar, Vikram, Krishnan, Jishnu K. S., Puthillathu, Narayanan, Namboodiri, Aryan M. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5454052/
https://www.ncbi.nlm.nih.gov/pubmed/28626388
http://dx.doi.org/10.3389/fnmol.2017.00161

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5454052/
https://www.ncbi.nlm.nih.gov/pubmed/28626388
http://dx.doi.org/10.3389/fnmol.2017.00161

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