Increasing N-acetylaspartate in the Brain during Postnatal Myelination Does Not Cause the CNS Pathologies of Canavan Disease

Canavan disease is caused by mutations in the gene encoding aspartoacylase (ASPA), a deacetylase that catabolizes N-acetylaspartate (NAA). The precise involvement of elevated NAA in the pathogenesis of Canavan disease is an ongoing debate. In the present study, we tested the effects of elevated NAA...

Descripción completa

Detalles Bibliográficos
Autores principales: Appu, Abhilash P., Moffett, John R., Arun, Peethambaran, Moran, Sean, Nambiar, Vikram, Krishnan, Jishnu K. S., Puthillathu, Narayanan, Namboodiri, Aryan M. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5454052/
https://www.ncbi.nlm.nih.gov/pubmed/28626388
http://dx.doi.org/10.3389/fnmol.2017.00161

Ejemplares similares

Ejemplares similares