Cargando…

Genetic architecture of epigenetic and neuronal ageing rates in human brain regions

Identifying genes regulating the pace of epigenetic ageing represents a new frontier in genome-wide association studies (GWASs). Here using 1,796 brain samples from 1,163 individuals, we carry out a GWAS of two DNA methylation-based biomarkers of brain age: the epigenetic ageing rate and estimated p...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lu, Ake T., Hannon, Eilis, Levine, Morgan E., Crimmins, Eileen M., Lunnon, Katie, Mill, Jonathan, Geschwind, Daniel H., Horvath, Steve
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5454371/ https://www.ncbi.nlm.nih.gov/pubmed/28516910 http://dx.doi.org/10.1038/ncomms15353

Ejemplares similares

Genetic variants near MLST8 and DHX57 affect the epigenetic age of the cerebellum
por: Lu, Ake T., et al.
Publicado: (2016)

Interindividual methylomic variation across blood, cortex, and cerebellum: implications for epigenetic studies of neurological and neuropsychiatric phenotypes
por: Hannon, Eilis, et al.
Publicado: (2015)

Regional differences in mitochondrial DNA methylation in human post-mortem brain tissue
por: Devall, Matthew, et al.
Publicado: (2017)

Parallel profiling of DNA methylation and hydroxymethylation highlights neuropathology-associated epigenetic variation in Alzheimer’s disease
por: Smith, Adam R., et al.
Publicado: (2019)

Recalibrating the epigenetic clock: implications for assessing biological age in the human cortex
por: Shireby, Gemma L, et al.
Publicado: (2020)

DNA methylation signatures of Alzheimer’s disease neuropathology in the cortex are primarily driven by variation in non-neuronal cell-types
por: Shireby, Gemma, et al.
Publicado: (2022)

Variation in 5-hydroxymethylcytosine across human cortex and cerebellum
por: Lunnon, Katie, et al.
Publicado: (2016)

Erratum to: Variation in 5-hydroxymethylcytosine across human cortex and cerebellum
por: Lunnon, Katie, et al.
Publicado: (2016)

Genetic risk variants for brain disorders are enriched in cortical H3K27ac domains
por: Hannon, Eilis, et al.
Publicado: (2019)

Pleiotropic Effects of Trait-Associated Genetic Variation on DNA Methylation: Utility for Refining GWAS Loci
por: Hannon, Eilis, et al.
Publicado: (2017)

Evaluation of nanopore sequencing for epigenetic epidemiology: a comparison with DNA methylation microarrays
por: Flynn, Robert, et al.
Publicado: (2022)

Novel epigenetic clock for fetal brain development predicts prenatal age for cellular stem cell models and derived neurons
por: Steg, Leonard C., et al.
Publicado: (2021)

A role for Ca(V)1 and calcineurin signaling in depolarization-induced changes in neuronal DNA methylation
por: Hannon, Eilis, et al.
Publicado: (2015)

A new aging measure captures morbidity and mortality risk across diverse subpopulations from NHANES IV: A cohort study
por: Liu, Zuyun, et al.
Publicado: (2018)

Correction: A new aging measure captures morbidity and mortality risk across diverse subpopulations from NHANES IV: A cohort study
por: Liu, Zuyun, et al.
Publicado: (2019)

Epigenetic age of the pre-frontal cortex is associated with neuritic plaques, amyloid load, and Alzheimer’s disease related cognitive functioning
por: Levine, Morgan E., et al.
Publicado: (2015)

Which Risk Factors Causally Influence Dementia? A Systematic Review of Mendelian Randomization Studies
por: Kuźma, Elżbieta, et al.
Publicado: (2018)

Elevated DNA methylation across a 48-kb region spanning the HOXA gene cluster is associated with Alzheimer’s disease neuropathology
por: Smith, Rebecca G., et al.
Publicado: (2018)

Not All Smokers Die Young: A Model for Hidden Heterogeneity within the Human Population
por: Levine, Morgan, et al.
Publicado: (2014)

Systematic underestimation of the epigenetic clock and age acceleration in older subjects
por: El Khoury, Louis Y., et al.
Publicado: (2019)

Functional characterization of the schizophrenia associated gene AS3MT identifies a role in neuronal development
por: Washer, Sam J., et al.
Publicado: (2022)

Associations of Age, Sex, Race/Ethnicity, and Education With 13 Epigenetic Clocks in a Nationally Representative U.S. Sample: The Health and Retirement Study
por: Crimmins, Eileen M, et al.
Publicado: (2021)

Characterizing the properties of bisulfite sequencing data: maximizing power and sensitivity to identify between-group differences in DNA methylation
por: Seiler Vellame, Dorothea, et al.
Publicado: (2021)

EPIGENETIC PREDICTORS OF LIFESPAN AND HEALTHSPAN
por: Lu, Ake T, et al.
Publicado: (2019)

Epigenetic Signature of Childhood Adversity in Older Adults
por: Klopack, Eric, et al.
Publicado: (2021)

Age-associated changes in DNA methylation across multiple tissues in an inbred mouse model
por: Spiers, Helen, et al.
Publicado: (2016)

5-hydroxymethylcytosine is highly dynamic across human fetal brain development
por: Spiers, Helen, et al.
Publicado: (2017)

Epigenetic-based age acceleration in a representative sample of older Americans: Associations with aging-related morbidity and mortality
por: Faul, Jessica D., et al.
Publicado: (2023)

SHORT SLEEP AND INSOMNIA ARE ASSOCIATED WITH ACCELERATED EPIGENETIC AGE
por: Kusters, Cynthia, et al.
Publicado: (2022)

Occupational characteristics and epigenetic aging among older adults in the United States
por: Andrasfay, Theresa, et al.
Publicado: (2023)

EPIGENETIC CLOCKS OF COMPUTED TOMOGRAPHY MEASURES OF FATTY ORGANS
por: Lu, Ake T, et al.
Publicado: (2019)

Assessing the co-variability of DNA methylation across peripheral cells and tissues: Implications for the interpretation of findings in epigenetic epidemiology
por: Hannon, Eilis, et al.
Publicado: (2021)

Genetic risk for Alzheimer’s disease influences neuropathology via multiple biological pathways
por: Hannon, Eilis, et al.
Publicado: (2020)

Genome-wide characterization of mitochondrial DNA methylation in human brain
por: Devall, Matthew, et al.
Publicado: (2023)

Lifetime exposure to smoking, epigenetic aging, and morbidity and mortality in older adults
por: Klopack, Eric T., et al.
Publicado: (2022)

Transcriptional Signatures of Tau and Amyloid Neuropathology
por: Castanho, Isabel, et al.
Publicado: (2020)

Guidance for DNA methylation studies: statistical insights from the Illumina EPIC array
por: Mansell, Georgina, et al.
Publicado: (2019)

HIV-1 Infection Accelerates Age According to the Epigenetic Clock
por: Horvath, Steve, et al.
Publicado: (2015)

Schizophrenia-associated methylomic variation: molecular signatures of disease and polygenic risk burden across multiple brain regions
por: Viana, Joana, et al.
Publicado: (2017)

An overview of DNA methylation-derived trait score methods and applications
por: Nabais, Marta F., et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_r8kj8r171cvks6fg31e9od3429