Maternal age-dependent APC/C-mediated decrease in securin causes premature sister chromatid separation in meiosis II

Sister chromatid attachment during meiosis II (MII) is maintained by securin-mediated inhibition of separase. In maternal ageing, oocytes show increased inter-sister kinetochore distance and premature sister chromatid separation (PSCS), suggesting aberrant separase activity. Here, we find that MII o...

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Detalles Bibliográficos
Autores principales: Nabti, Ibtissem, Grimes, Rosanna, Sarna, Hema, Marangos, Petros, Carroll, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5454377/
https://www.ncbi.nlm.nih.gov/pubmed/28516917
http://dx.doi.org/10.1038/ncomms15346

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5454377/
https://www.ncbi.nlm.nih.gov/pubmed/28516917
http://dx.doi.org/10.1038/ncomms15346

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