Improving 10-deacetylbaccatin III-10-β-O-acetyltransferase catalytic fitness for Taxol production

The natural concentration of the anticancer drug Taxol is about 0.02% in yew trees, whereas that of its analogue 7-β-xylosyl-10-deacetyltaxol is up to 0.5%. While this compound is not an intermediate in Taxol biosynthetic route, it can be converted into Taxol by de-glycosylation and acetylation. Her...

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Detalles Bibliográficos
Autores principales: Li, Bing-Juan, Wang, Hao, Gong, Ting, Chen, Jing-Jing, Chen, Tian-Jiao, Yang, Jin-Ling, Zhu, Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5454391/
https://www.ncbi.nlm.nih.gov/pubmed/28516951
http://dx.doi.org/10.1038/ncomms15544

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5454391/
https://www.ncbi.nlm.nih.gov/pubmed/28516951
http://dx.doi.org/10.1038/ncomms15544

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