A Conserved Residue, Tyrosine (Y) 84, in H5N1 Influenza A Virus NS1 Regulates IFN Signaling Responses to Enhance Viral Infection

The non-structural protein, NS1, is a virulence factor encoded by influenza A viruses (IAVs). In this report, we provide evidence that the conserved residue, tyrosine (Y) 84, in a conserved putative SH2-binding domain in A/Duck/Hubei/2004/L-1 [H5N1] NS1 is critical for limiting an interferon (IFN) r...

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Detalles Bibliográficos
Autores principales: Wang, Ben X., Wei, Lianhu, Kotra, Lakshmi P., Brown, Earl G., Fish, Eleanor N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5454420/
https://www.ncbi.nlm.nih.gov/pubmed/28498306
http://dx.doi.org/10.3390/v9050107

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5454420/
https://www.ncbi.nlm.nih.gov/pubmed/28498306
http://dx.doi.org/10.3390/v9050107

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