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A FKBP5 mutation is associated with Paget's disease of bone and enhances osteoclastogenesis
Paget's disease of bone (PDB) is a common metabolic bone disease that is characterized by aberrant focal bone remodeling, which is caused by excessive osteoclastic bone resorption followed by disorganized osteoblastic bone formation. Genetic factors are a critical determinant of PDB pathogenesi...
Autores principales: | Lu, Bingru, Jiao, Yulian, Wang, Yinchang, Dong, Jing, Wei, Muyun, Cui, Bin, Sun, Yafang, Wang, Laicheng, Zhang, Bingchang, Chen, Zijiang, Zhao, Yueran |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5454451/ https://www.ncbi.nlm.nih.gov/pubmed/28524179 http://dx.doi.org/10.1038/emm.2017.64 |
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