Mistranslation can enhance fitness through purging of deleterious mutations

Phenotypic mutations are amino acid changes caused by mistranslation. How phenotypic mutations affect the adaptive evolution of new protein functions is unknown. Here we evolve the antibiotic resistance protein TEM-1 towards resistance on the antibiotic cefotaxime in an Escherichia coli strain with...

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Detalles Bibliográficos
Autores principales: Bratulic, Sinisa, Toll-Riera, Macarena, Wagner, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5454534/
https://www.ncbi.nlm.nih.gov/pubmed/28524864
http://dx.doi.org/10.1038/ncomms15410

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5454534/
https://www.ncbi.nlm.nih.gov/pubmed/28524864
http://dx.doi.org/10.1038/ncomms15410

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