3D-QSAR, Molecular Docking and Molecular Dynamics Simulation of Pseudomonas aeruginosa LpxC Inhibitors

As an important target for the development of novel antibiotics, UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase (LpxC) has been widely studied. Pyridone methylsulfone hydroxamate (PMH) compounds can effectively inhibit the catalytic activity of LpxC. In this work, the three-dimension...

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Detalles Bibliográficos
Autores principales: Zuo, Ke, Liang, Li, Du, Wenyi, Sun, Xin, Liu, Wei, Gou, Xiaojun, Wan, Hua, Hu, Jianping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5454807/
https://www.ncbi.nlm.nih.gov/pubmed/28481250
http://dx.doi.org/10.3390/ijms18050761

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5454807/
https://www.ncbi.nlm.nih.gov/pubmed/28481250
http://dx.doi.org/10.3390/ijms18050761

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