Zampanolide, a Microtubule-Stabilizing Agent, Is Active in Resistant Cancer Cells and Inhibits Cell Migration

Zampanolide, first discovered in a sponge extract in 1996 and later identified as a microtubule-stabilizing agent in 2009, is a covalent binding secondary metabolite with potent, low nanomolar activity in mammalian cells. Zampanolide was not susceptible to single amino acid mutations at the taxoid s...

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Detalles Bibliográficos
Autores principales: Field, Jessica J., Northcote, Peter T., Paterson, Ian, Altmann, Karl-Heinz, Díaz, J. Fernando, Miller, John H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5454884/
https://www.ncbi.nlm.nih.gov/pubmed/28467385
http://dx.doi.org/10.3390/ijms18050971

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5454884/
https://www.ncbi.nlm.nih.gov/pubmed/28467385
http://dx.doi.org/10.3390/ijms18050971

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