BDNF Binds Its Pro-Peptide with High Affinity and the Common Val66Met Polymorphism Attenuates the Interaction

Most growth factors are initially synthesized as precursors then cleaved into bioactive mature domains and pro-domains, but the biological roles of pro-domains are poorly understood. In the present study, we investigated the pro-domain (or pro-peptide) of brain-derived neurotrophic factor (BDNF), wh...

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Detalles Bibliográficos
Autores principales: Uegaki, Koichi, Kumanogoh, Haruko, Mizui, Toshiyuki, Hirokawa, Takatsugu, Ishikawa, Yasuyuki, Kojima, Masami
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5454954/
https://www.ncbi.nlm.nih.gov/pubmed/28498321
http://dx.doi.org/10.3390/ijms18051042

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5454954/
https://www.ncbi.nlm.nih.gov/pubmed/28498321
http://dx.doi.org/10.3390/ijms18051042

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