The Lys-Asp-Tyr Triad within the Mite Allergen Der p 1 Propeptide Is a Critical Structural Element for the pH-Dependent Initiation of the Protease Maturation

The major house dust mite allergen, Der p 1, is a papain-like cysteine protease expressed as an inactive precursor, proDer p 1, carrying an N-terminal propeptide with a unique structure. The maturation of the zymogen into an enzymatically-active form of Der p 1 is a multistep autocatalytic process i...

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Detalles Bibliográficos
Autores principales: Chevigné, Andy, Campizi, Vincenzo, Szpakowska, Martyna, Bourry, David, Dumez, Marie-Eve, Martins, José C., Matagne, André, Galleni, Moreno, Jacquet, Alain
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5454996/
https://www.ncbi.nlm.nih.gov/pubmed/28531096
http://dx.doi.org/10.3390/ijms18051087

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5454996/
https://www.ncbi.nlm.nih.gov/pubmed/28531096
http://dx.doi.org/10.3390/ijms18051087

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