Cargando…

The Lys-Asp-Tyr Triad within the Mite Allergen Der p 1 Propeptide Is a Critical Structural Element for the pH-Dependent Initiation of the Protease Maturation

The major house dust mite allergen, Der p 1, is a papain-like cysteine protease expressed as an inactive precursor, proDer p 1, carrying an N-terminal propeptide with a unique structure. The maturation of the zymogen into an enzymatically-active form of Der p 1 is a multistep autocatalytic process i...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chevigné, Andy, Campizi, Vincenzo, Szpakowska, Martyna, Bourry, David, Dumez, Marie-Eve, Martins, José C., Matagne, André, Galleni, Moreno, Jacquet, Alain
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5454996/ https://www.ncbi.nlm.nih.gov/pubmed/28531096 http://dx.doi.org/10.3390/ijms18051087

Ejemplares similares

Profiling the Extended Cleavage Specificity of the House Dust Mite Protease Allergens Der p 1, Der p 3 and Der p 6 for the Prediction of New Cell Surface Protein Substrates
por: Jacquet, Alain, et al.
Publicado: (2017)

Orchestration of an Uncommon Maturation Cascade of the House Dust Mite Protease Allergen Quartet
por: Dumez, Marie-Eve, et al.
Publicado: (2014)

The Proline-Rich Motif of the proDer p 3 Allergen Propeptide Is Crucial for Protease-Protease Interaction
por: Dumez, Marie-Eve, et al.
Publicado: (2013)

Der p 5 allergen from house dust mite: first epitope mapping of rabbit IgG blocking antibodies
por: Lahiani, S., et al.
Publicado: (2018)

Antibacterial mechanism of the Asp-Asp-Asp-Tyr peptide
por: Zhuang, Shanshan, et al.
Publicado: (2022)

Penetrance of Hemochromatosis in HFE Genotypes Resulting in p.Cys282Tyr and p.[Cys282Tyr];[His63Asp] in the eMERGE Network
por: Gallego, Carlos J., et al.
Publicado: (2015)

Evaluating the role of CHEK2 p.(Asp438Tyr) allele in inherited breast cancer predisposition
por: Kumpula, Timo A., et al.
Publicado: (2023)

Characterization of a lytic Pseudomonas aeruginosa phage vB_PaeP_ASP23 and functional analysis of its lysin LysASP and holin HolASP
por: Cui, Jiaqi, et al.
Publicado: (2023)

Characterization of Innate Immune Responses to House Dust Mite Allergens: Pitfalls and Limitations
por: Jacquet, Alain
Publicado: (2021)

Tyr‐Asp inhibition of glyceraldehyde 3‐phosphate dehydrogenase affects plant redox metabolism
por: Moreno, Juan C, et al.
Publicado: (2021)

When mites attack: domestic mites are not just allergens
por: Cui, Yubao
Publicado: (2014)

Isolation of Carbene‐Stabilized Arsenic Monophosphide [AsP] and its Radical Cation [AsP](+.) and Dication [AsP](2+)
por: Doddi, Adinarayana, et al.
Publicado: (2019)

Antagonism of Protease Activated Receptor-2 by GB88 Reduces Inflammation Triggered by Protease Allergen Tyr-p3
por: Wang, Yun-Ju, et al.
Publicado: (2021)

Determination of Hexapeptide ALA-ASP-LEU-LYS-PRO-THR by MALDI MS
por: Olejnik, Anna, et al.
Publicado: (2012)

Effects of Ser47-Point Mutation on Conformation Structure and Allergenicity of the Allergen of Der p 2, a Major House Dust Mite Allergen
por: Kulwanich, Bhakkawarat, et al.
Publicado: (2018)

Antinociceptive potency of a fluorinated cyclopeptide Dmt-c[D-Lys-Phe-p-CF(3)-Phe-Asp]NH(2)
por: Piekielna-Ciesielska, Justyna, et al.
Publicado: (2018)

Consideration of methods for identifying mite allergens
por: Cui, Yubao, et al.
Publicado: (2018)

IgE-binding residues analysis of the house dust mite allergen Der p 23
por: Pang, Sze Lei, et al.
Publicado: (2021)

The soluble form of pan-RTK inhibitor and tumor suppressor LRIG1 mediates downregulation of AXL through direct protein–protein interaction in glioblastoma
por: Neirinckx, Virginie, et al.
Publicado: (2019)

Familial congenital cyanosis caused by Hb-M(Yantai)(α-76 GAC → TAC, Asp → Tyr)
por: Sun, Yanbo, et al.
Publicado: (2010)

Allergen Delivery Inhibitors: Characterisation of Potent and Selective Inhibitors of Der p 1 and Their Attenuation of Airway Responses to House Dust Mite Allergens
por: Zhang, Jihui, et al.
Publicado: (2018)

Adenovirus Precursor pVII Protein Stability Is Regulated By Its Propeptide Sequence
por: Inturi, Raviteja, et al.
Publicado: (2013)

Variation in allergen content in sublingual allergen immunotherapy with house dust mites
por: Moreno Benítez, F., et al.
Publicado: (2015)

A Simple & Convenient Solid Phase Synthesis of Bacterial Origin Octapeptide Sequence, Glu-Asp-Gly-Asn-Lys-Pro-Gly-Lys-OH
por: Khan, Riaz A.
Publicado: (2010)

Characterization and Evolutionary Implications of the Triad Asp-Xxx-Glu in Group II Phosphopantetheinyl Transferases
por: Wang, Yue-Yue, et al.
Publicado: (2014)

O14 - Der p 10 as a minor allergen in children sensitised to house dust mites
por: Lafuente, Isabel, et al.
Publicado: (2014)

IgE Epitopes of the House Dust Mite Allergen Der p 7 Are Mainly Discontinuous and Conformational
por: Curin, Mirela, et al.
Publicado: (2021)

Proadrenomedullin N-Terminal 20 Peptides (PAMPs) Are Agonists of the Chemokine Scavenger Receptor ACKR3/CXCR7
por: Meyrath, Max, et al.
Publicado: (2021)

Patient-Oriented Perspective on Chemokine Receptor Expression and Function in Glioma
por: Isci, Damla, et al.
Publicado: (2021)

New pairings and deorphanization among the atypical chemokine receptor family — physiological and clinical relevance
por: Szpakowska, Martyna, et al.
Publicado: (2023)

Computational Design of α-AsP/γ-AsP Vertical Two-Dimensional Homojunction for Photovoltaic Applications
por: Mao, Yuliang, et al.
Publicado: (2022)

Localization of the Lys, Asp, Glu, Leu tetrapeptide receptor to the Golgi complex and the intermediate compartment in mammalian cells
Publicado: (1994)

Molecular, Structural and Immunological Characterization of Der p 18, a Chitinase-Like House Dust Mite Allergen
por: Resch, Yvonne, et al.
Publicado: (2016)

Innate function of house dust mite allergens: robust enzymatic degradation of extracellular matrix at elevated pH
por: Oida, Kumiko, et al.
Publicado: (2017)

The natural analgesic conolidine targets the newly identified opioid scavenger ACKR3/CXCR7
por: Szpakowska, Martyna, et al.
Publicado: (2021)

Variability of house dust mite allergen exposure in dwellings.
por: Hirsch, T, et al.
Publicado: (1998)

Allergens with Protease Activity from House Dust Mites
por: Reithofer, Manuel, et al.
Publicado: (2017)

Increased cardiogenesis in P19-GFP teratocarcinoma cells expressing the propeptide IGF-1Ea
por: Poudel, Bhawana, et al.
Publicado: (2011)

Class A β-Lactamases as Versatile Scaffolds to Create Hybrid Enzymes: Applications from Basic Research to Medicine
por: Huynen, Céline, et al.
Publicado: (2013)

XPD Asp312Asn and Lys751Gln polymorphisms and breast cancer susceptibility: A meta-analysis
por: Yan, Yulan, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_pua569osubdftrn55r25dc7qhl