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Simple adjustment of the sequence weight algorithm remarkably enhances PSI-BLAST performance
BACKGROUND: PSI-BLAST, an extremely popular tool for sequence similarity search, features the utilization of Position-Specific Scoring Matrix (PSSM) constructed from a multiple sequence alignment (MSA). PSSM allows the detection of more distant homologs than a general amino acid substitution matrix...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5455086/ https://www.ncbi.nlm.nih.gov/pubmed/28578660 http://dx.doi.org/10.1186/s12859-017-1686-9 |