Preparation of pH Sensitive Pluronic-Docetaxel Conjugate Micelles to Balance the Stability and Controlled Release Issues

A novel polymer-drug conjugate was prepared by the chemical reaction between the copolymer Pluronic P123 and the docetaxel via a pH sensitive hydrazone bond. These pluronic P123-docetaxel (DTX) conjugates (P123-DTX) could form the stable drug-loaded materials that can self-assemble into the defined...

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Detalles Bibliográficos
Autores principales: Liang, Yanchao, Su, Zhihui, Yao, Yao, Zhang, Na
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5455281/
https://www.ncbi.nlm.nih.gov/pubmed/28787944
http://dx.doi.org/10.3390/ma8020379

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5455281/
https://www.ncbi.nlm.nih.gov/pubmed/28787944
http://dx.doi.org/10.3390/ma8020379

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