Suppression of IL-12p70 formation by IL-2 or following macrophage depletion causes T-cell autoreactivity leading to CNS demyelination in HSV-1-infected mice

We have established two mouse models of central nervous system (CNS) demyelination that differ from most other available models of multiple sclerosis (MS) in that they represent a mixture of viral and immune triggers. In the first model, ocular infection of different strains of mice with a recombina...

Descripción completa

Detalles Bibliográficos
Autores principales: Lee, Dhong Hyun, Zandian, Mandana, Kuo, Jane, Mott, Kevin R., Chen, Shuang, Arditi, Moshe, Ghiasi, Homayon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5456410/
https://www.ncbi.nlm.nih.gov/pubmed/28542613
http://dx.doi.org/10.1371/journal.ppat.1006401

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5456410/
https://www.ncbi.nlm.nih.gov/pubmed/28542613
http://dx.doi.org/10.1371/journal.ppat.1006401

Ejemplares similares