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Novel Resorbable and Osteoconductive Calcium Silicophosphate Scaffold Induced Bone Formation

This aim of this research was to develop a novel ceramic scaffold to evaluate the response of bone after ceramic implantation in New Zealand (NZ) rabbits. Ceramics were prepared by the polymer replication method and inserted into NZ rabbits. Macroporous scaffolds with interconnected round-shaped por...

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Autores principales: Ros-Tárraga, Patricia, Mazón, Patricia, Rodríguez, Miguel A., Meseguer-Olmo, Luis, De Aza, Piedad N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5457066/
https://www.ncbi.nlm.nih.gov/pubmed/28773906
http://dx.doi.org/10.3390/ma9090785
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author Ros-Tárraga, Patricia
Mazón, Patricia
Rodríguez, Miguel A.
Meseguer-Olmo, Luis
De Aza, Piedad N.
author_facet Ros-Tárraga, Patricia
Mazón, Patricia
Rodríguez, Miguel A.
Meseguer-Olmo, Luis
De Aza, Piedad N.
author_sort Ros-Tárraga, Patricia
collection PubMed
description This aim of this research was to develop a novel ceramic scaffold to evaluate the response of bone after ceramic implantation in New Zealand (NZ) rabbits. Ceramics were prepared by the polymer replication method and inserted into NZ rabbits. Macroporous scaffolds with interconnected round-shaped pores (0.5–1.5 mm = were prepared). The scaffold acted as a physical support where cells with osteoblastic capability were found to migrate, develop processes, and newly immature and mature bone tissue colonized on the surface (initially) and in the material’s interior. The new ceramic induced about 62.18% ± 2.28% of new bone and almost complete degradation after six healing months. An elemental analysis showed that the gradual diffusion of Ca and Si ions from scaffolds into newly formed bone formed part of the biomaterial’s resorption process. Histological and radiological studies demonstrated that this porous ceramic scaffold showed biocompatibility and excellent osteointegration and osteoinductive capacity, with no interposition of fibrous tissue between the implanted material and the hematopoietic bone marrow interphase, nor any immune response after six months of implantation. No histological changes were observed in the various organs studied (para-aortic lymph nodes, liver, kidney and lung) as a result of degradation products being released.
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spelling pubmed-54570662017-07-28 Novel Resorbable and Osteoconductive Calcium Silicophosphate Scaffold Induced Bone Formation Ros-Tárraga, Patricia Mazón, Patricia Rodríguez, Miguel A. Meseguer-Olmo, Luis De Aza, Piedad N. Materials (Basel) Article This aim of this research was to develop a novel ceramic scaffold to evaluate the response of bone after ceramic implantation in New Zealand (NZ) rabbits. Ceramics were prepared by the polymer replication method and inserted into NZ rabbits. Macroporous scaffolds with interconnected round-shaped pores (0.5–1.5 mm = were prepared). The scaffold acted as a physical support where cells with osteoblastic capability were found to migrate, develop processes, and newly immature and mature bone tissue colonized on the surface (initially) and in the material’s interior. The new ceramic induced about 62.18% ± 2.28% of new bone and almost complete degradation after six healing months. An elemental analysis showed that the gradual diffusion of Ca and Si ions from scaffolds into newly formed bone formed part of the biomaterial’s resorption process. Histological and radiological studies demonstrated that this porous ceramic scaffold showed biocompatibility and excellent osteointegration and osteoinductive capacity, with no interposition of fibrous tissue between the implanted material and the hematopoietic bone marrow interphase, nor any immune response after six months of implantation. No histological changes were observed in the various organs studied (para-aortic lymph nodes, liver, kidney and lung) as a result of degradation products being released. MDPI 2016-09-20 /pmc/articles/PMC5457066/ /pubmed/28773906 http://dx.doi.org/10.3390/ma9090785 Text en © 2016 by the authors; Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ros-Tárraga, Patricia
Mazón, Patricia
Rodríguez, Miguel A.
Meseguer-Olmo, Luis
De Aza, Piedad N.
Novel Resorbable and Osteoconductive Calcium Silicophosphate Scaffold Induced Bone Formation
title Novel Resorbable and Osteoconductive Calcium Silicophosphate Scaffold Induced Bone Formation
title_full Novel Resorbable and Osteoconductive Calcium Silicophosphate Scaffold Induced Bone Formation
title_fullStr Novel Resorbable and Osteoconductive Calcium Silicophosphate Scaffold Induced Bone Formation
title_full_unstemmed Novel Resorbable and Osteoconductive Calcium Silicophosphate Scaffold Induced Bone Formation
title_short Novel Resorbable and Osteoconductive Calcium Silicophosphate Scaffold Induced Bone Formation
title_sort novel resorbable and osteoconductive calcium silicophosphate scaffold induced bone formation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5457066/
https://www.ncbi.nlm.nih.gov/pubmed/28773906
http://dx.doi.org/10.3390/ma9090785
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