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A Mathematical Model on the Resolution of Extrusion Bioprinting for the Development of New Bioinks

Pneumatic extrusion-based bioprinting is a recent and interesting technology that is very useful for biomedical applications. However, many process parameters in the bioprinter need to be fully understood in order to print at an adequate resolution. In this paper, a simple yet accurate mathematical...

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Detalles Bibliográficos
Autores principales: Suntornnond, Ratima, Tan, Edgar Yong Sheng, An, Jia, Chua, Chee Kai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5457067/
https://www.ncbi.nlm.nih.gov/pubmed/28773879
http://dx.doi.org/10.3390/ma9090756
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author Suntornnond, Ratima
Tan, Edgar Yong Sheng
An, Jia
Chua, Chee Kai
author_facet Suntornnond, Ratima
Tan, Edgar Yong Sheng
An, Jia
Chua, Chee Kai
author_sort Suntornnond, Ratima
collection PubMed
description Pneumatic extrusion-based bioprinting is a recent and interesting technology that is very useful for biomedical applications. However, many process parameters in the bioprinter need to be fully understood in order to print at an adequate resolution. In this paper, a simple yet accurate mathematical model to predict the printed width of a continuous hydrogel line is proposed, in which the resolution is expressed as a function of nozzle size, pressure, and printing speed. A thermo-responsive hydrogel, pluronic F127, is used to validate the model predictions. This model could provide a platform for future correlation studies on pneumatic extrusion-based bioprinting as well as for developing new bioink formulations.
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spelling pubmed-54570672017-07-28 A Mathematical Model on the Resolution of Extrusion Bioprinting for the Development of New Bioinks Suntornnond, Ratima Tan, Edgar Yong Sheng An, Jia Chua, Chee Kai Materials (Basel) Article Pneumatic extrusion-based bioprinting is a recent and interesting technology that is very useful for biomedical applications. However, many process parameters in the bioprinter need to be fully understood in order to print at an adequate resolution. In this paper, a simple yet accurate mathematical model to predict the printed width of a continuous hydrogel line is proposed, in which the resolution is expressed as a function of nozzle size, pressure, and printing speed. A thermo-responsive hydrogel, pluronic F127, is used to validate the model predictions. This model could provide a platform for future correlation studies on pneumatic extrusion-based bioprinting as well as for developing new bioink formulations. MDPI 2016-09-06 /pmc/articles/PMC5457067/ /pubmed/28773879 http://dx.doi.org/10.3390/ma9090756 Text en © 2016 by the authors; Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Suntornnond, Ratima
Tan, Edgar Yong Sheng
An, Jia
Chua, Chee Kai
A Mathematical Model on the Resolution of Extrusion Bioprinting for the Development of New Bioinks
title A Mathematical Model on the Resolution of Extrusion Bioprinting for the Development of New Bioinks
title_full A Mathematical Model on the Resolution of Extrusion Bioprinting for the Development of New Bioinks
title_fullStr A Mathematical Model on the Resolution of Extrusion Bioprinting for the Development of New Bioinks
title_full_unstemmed A Mathematical Model on the Resolution of Extrusion Bioprinting for the Development of New Bioinks
title_short A Mathematical Model on the Resolution of Extrusion Bioprinting for the Development of New Bioinks
title_sort mathematical model on the resolution of extrusion bioprinting for the development of new bioinks
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5457067/
https://www.ncbi.nlm.nih.gov/pubmed/28773879
http://dx.doi.org/10.3390/ma9090756
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