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A Mathematical Model on the Resolution of Extrusion Bioprinting for the Development of New Bioinks
Pneumatic extrusion-based bioprinting is a recent and interesting technology that is very useful for biomedical applications. However, many process parameters in the bioprinter need to be fully understood in order to print at an adequate resolution. In this paper, a simple yet accurate mathematical...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5457067/ https://www.ncbi.nlm.nih.gov/pubmed/28773879 http://dx.doi.org/10.3390/ma9090756 |
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author | Suntornnond, Ratima Tan, Edgar Yong Sheng An, Jia Chua, Chee Kai |
author_facet | Suntornnond, Ratima Tan, Edgar Yong Sheng An, Jia Chua, Chee Kai |
author_sort | Suntornnond, Ratima |
collection | PubMed |
description | Pneumatic extrusion-based bioprinting is a recent and interesting technology that is very useful for biomedical applications. However, many process parameters in the bioprinter need to be fully understood in order to print at an adequate resolution. In this paper, a simple yet accurate mathematical model to predict the printed width of a continuous hydrogel line is proposed, in which the resolution is expressed as a function of nozzle size, pressure, and printing speed. A thermo-responsive hydrogel, pluronic F127, is used to validate the model predictions. This model could provide a platform for future correlation studies on pneumatic extrusion-based bioprinting as well as for developing new bioink formulations. |
format | Online Article Text |
id | pubmed-5457067 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-54570672017-07-28 A Mathematical Model on the Resolution of Extrusion Bioprinting for the Development of New Bioinks Suntornnond, Ratima Tan, Edgar Yong Sheng An, Jia Chua, Chee Kai Materials (Basel) Article Pneumatic extrusion-based bioprinting is a recent and interesting technology that is very useful for biomedical applications. However, many process parameters in the bioprinter need to be fully understood in order to print at an adequate resolution. In this paper, a simple yet accurate mathematical model to predict the printed width of a continuous hydrogel line is proposed, in which the resolution is expressed as a function of nozzle size, pressure, and printing speed. A thermo-responsive hydrogel, pluronic F127, is used to validate the model predictions. This model could provide a platform for future correlation studies on pneumatic extrusion-based bioprinting as well as for developing new bioink formulations. MDPI 2016-09-06 /pmc/articles/PMC5457067/ /pubmed/28773879 http://dx.doi.org/10.3390/ma9090756 Text en © 2016 by the authors; Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Suntornnond, Ratima Tan, Edgar Yong Sheng An, Jia Chua, Chee Kai A Mathematical Model on the Resolution of Extrusion Bioprinting for the Development of New Bioinks |
title | A Mathematical Model on the Resolution of Extrusion Bioprinting for the Development of New Bioinks |
title_full | A Mathematical Model on the Resolution of Extrusion Bioprinting for the Development of New Bioinks |
title_fullStr | A Mathematical Model on the Resolution of Extrusion Bioprinting for the Development of New Bioinks |
title_full_unstemmed | A Mathematical Model on the Resolution of Extrusion Bioprinting for the Development of New Bioinks |
title_short | A Mathematical Model on the Resolution of Extrusion Bioprinting for the Development of New Bioinks |
title_sort | mathematical model on the resolution of extrusion bioprinting for the development of new bioinks |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5457067/ https://www.ncbi.nlm.nih.gov/pubmed/28773879 http://dx.doi.org/10.3390/ma9090756 |
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