Down regulation of macrophage IFNGR1 exacerbates systemic L. monocytogenes infection

Interferons (IFNs) target macrophages to regulate inflammation and resistance to microbial infections. The type II IFN (IFNγ) acts on a cell surface receptor (IFNGR) to promote gene expression that enhance macrophage inflammatory and anti-microbial activity. Type I IFNs can dampen macrophage respons...

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Detalles Bibliográficos
Autores principales: Eshleman, Emily M., Delgado, Christine, Kearney, Staci J., Friedman, Rachel S., Lenz, Laurel L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5457163/
https://www.ncbi.nlm.nih.gov/pubmed/28542482
http://dx.doi.org/10.1371/journal.ppat.1006388

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5457163/
https://www.ncbi.nlm.nih.gov/pubmed/28542482
http://dx.doi.org/10.1371/journal.ppat.1006388

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