Ancestral protein resurrection and engineering opportunities of the mamba aminergic toxins

Mamba venoms contain a multiplicity of three-finger fold aminergic toxins known to interact with various α-adrenergic, muscarinic and dopaminergic receptors with different pharmacological profiles. In order to generate novel functions on this structural scaffold and to avoid the daunting task of pro...

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Detalles Bibliográficos
Autores principales: Blanchet, Guillaume, Alili, Doria, Protte, Adèle, Upert, Gregory, Gilles, Nicolas, Tepshi, Livia, Stura, Enrico A., Mourier, Gilles, Servent, Denis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5457417/
https://www.ncbi.nlm.nih.gov/pubmed/28578406
http://dx.doi.org/10.1038/s41598-017-02953-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5457417/
https://www.ncbi.nlm.nih.gov/pubmed/28578406
http://dx.doi.org/10.1038/s41598-017-02953-0

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